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Article

Sumoylation and ubiquitylation crosstalk in the control of ΔNp63α protein stability.

Gene - 1 Mar 2018

Ranieri Michela, Vivo Maria, De Simone Marco, Guerrini Luisa, Pollice Alessandra, La Mantia Girolama, Calabrò Viola

Abstract excerpt

ΔNp63α is finely and strictly regulated during embryogenesis and differentiation. ΔNp63α is the only p63 isoform degraded by the proteasome after Ubiquitin and SUMO (Small Ubiquitin-like MOdifier) conjugation. Here, we show that p63 ubiquitylation per se is not the signal triggering p63 proteasomal degradation. Taking advantage of natural ΔNp63α mutants isolated by patients with Split Hand and Foot Malformation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29246538
DOI: 10.1016/j.gene.2017.12.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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