Article
Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype.
Cell cycle (Georgetown, Tex.) - 1 Dec 2004
Huang Yi-Ping, Wu Guojun, Guo Zhongmin, Osada Motonobu, Fomenkov Tanya, Park Hannah Lui, Trink Barry, Sidransky David, Fomenkov Alexey, Ratovitski Edward A
Abstract excerpt
p63 mutations have been identified in several developmental abnormalities, including split-hand/foot malformation (SHFM). In this study, we demonstrate that the C-terminal domain of p63alpha associates with the E2 ubiquitin conjugating enzyme, Ubc9. A p63alpha mutation, Q634X, which naturally occurs in SHFM modulated the interaction of p63alpha with Ubc9 in yeast genetic assay. Furthermore, Ubc9 catalyzed the...
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