Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CSF neurofilament light concentration is increased in presymptomatic CHMP2B mutation carriers.

Neurology - 9 Jan 2018

Rostgaard Nina, Roos Peter, Portelius Erik, Blennow Kaj, Zetterberg Henrik, Simonsen Anja H, Nielsen Jørgen E

Abstract excerpt

OBJECTIVE: A rare cause of familial frontotemporal dementia (FTD) is a mutation in the CHMP2B gene on chromosome 3 (FTD-3), described in a Danish family. Here we examine whether CSF biomarkers change in the preclinical phase of the disease. METHODS: In this cross-sectional explorative study, we analyzed CSF samples from 16 mutation carriers and 14 noncarriers from the Danish FTD-3 family. CSF biomarkers included...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Chitinase-3-Like Protein 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endosomal Sorting Complexes Required for Transport

Share to Family

Share to Frontotemporal Dementia

Share to Neurofilament Proteins

Share to Prodromal Symptoms

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 29237796
DOI: 10.1212/WNL.0000000000004799
PMCID: PMC5772154

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CSF neurofilament light concentration is increased in presymptomatic CHMP2B mutation carriers.PMID 29237796Read ↗

Serum Neurofilament Light in Patients with Frontotemporal Dementia Caused by CHMP2B Mutation.Semantic proximity Read ↗

Neurofilament light chain: a biomarker for genetic frontotemporal dementiaSemantic proximity Read ↗

Blood-Based Biomarkers in Frontotemporal Dementia: A Narrative Review.Semantic proximity Read ↗

Neurochemical biomarkers in the diagnosis of frontotemporal lobar degeneration: an updateSemantic proximity Read ↗

Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias.Semantic proximity Read ↗

The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in developmentSemantic proximity Read ↗

Diagnostic and prognostic value of plasma neurofilament light and total-tau in sporadic Creutzfeldt-Jakob diseaseSemantic proximity Read ↗

CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementiaSemantic proximity Read ↗

Cerebrospinal fluid neurofilament light chain as a biomarker of neurodegeneration in the Tg4510 and MitoPark mouse models.Semantic proximity Read ↗

Serum neurofilament light chain as a surrogate of cognitive decline in sporadic and familial frontotemporal dementiaSemantic proximity Read ↗

Fluid biomarkers in frontotemporal dementia: past, present and futureSemantic proximity Read ↗

Alterations in Lysosomal, Glial and Neurodegenerative Biomarkers in Patients with Sporadic and Genetic Forms of Frontotemporal DementiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.