Article
Aberrant prostaglandin synthase 2 expression defines an antigen-presenting cell defect for insulin-dependent diabetes mellitus.
The Journal of clinical investigation - 1 Aug 1999
Litherland S A, Xie X T, Hutson A D, Wasserfall C, Whittaker D S, She J X, Hofig A, Dennis M A, Fuller K, Cook R, Schatz D, Moldawer L L, Clare-Salzler M J
Abstract excerpt
Prostaglandins (PGs) are lipid molecules that profoundly affect cellular processes including inflammation and immune response. Pathways contributing to PG output are highly regulated in antigen-presenting cells such as macrophages and monocytes, which produce large quantities of these molecules upon activation. In this report, we demonstrate aberrant constitutive expression of the normally inducible...
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