Article
Evaluation of epidermal growth factor receptor signaling effects in gastric cancer cell lines by detailed motility-focused phenotypic characterization linked with molecular analysis.
BMC cancer - 13 Dec 2017
Keller Simone, Kneissl Julia, Grabher-Meier Verena, Heindl Stefan, Hasenauer Jan, Maier Dieter, Mattes Julian, Winter Peter, Luber Birgit
Abstract excerpt
BACKGROUND: Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR with the inhibitory antibody cetuximab may affect the motile and invasive behavior of tumor cells. Here, we evaluated the effects of EGFR signaling in gastric cancer cell lines to link the...
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