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Article

Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines.

BMC cancer - 28 Oct 2020

Ebert Karolin, Zwingenberger Gwen, Barbaria Elena, Keller Simone, Heck Corinna, Arnold Rouven, Hollerieth Vanessa, Mattes Julian, Geffers Robert, Raimúndez Elba, Hasenauer Jan, Luber Birgit

Abstract excerpt

BACKGROUND: Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The molecular mechanisms of action for anti-HER-family drugs in gastric cancer cells are incompletely understood. We compared the molecular effects of trastuzumab and the other HER-family targeting drugs cetuximab and afatinib on phosphoprotein and gene expression level to gain insights...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33115415
DOI: 10.1186/s12885-020-07540-7
PMCID: PMC7594334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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