Article
In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor (EGFR) expression and mutational phenotype.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association - 1 Jul 2012
Hotz Birgit, Keilholz Ulrich, Fusi Alberto, Buhr Heinz J, Hotz Hubert G
Abstract excerpt
BACKGROUND: Targeting the epidermal growth factor receptor (EGFR) pathway is an important approach for a variety of tumors. This study assessed the effect of cetuximab, an anti-EGFR monoclonal antibody, on three gastric cancer cell lines with different phenotypes in vitro and in a therapeutic orthotopic murine gastric cancer model. METHODS: Three human gastric cancer cell lines (AGS, MKN-45, NCI-N87) were...
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