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Article

Genetic Determinants of Intraocular Pressure.

Annual review of vision science - 15 Sept 2021

Xu Zihe, Hysi Pirro, Khawaja Anthony P

Abstract excerpt

Intraocular pressure (IOP) is the cardinal and only modifiable risk factor for glaucoma, the leading cause of irreparable blindness worldwide. Twin and family studies estimate the heritability of IOP to be 40-70%, and linkage studies for IOP have identified numerous loci. Mutations in MYOC can cause markedly elevated IOP and aggressive glaucoma often requiring surgical intervention. However, the majority of the...

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PMID: 34061569
DOI: 10.1146/annurev-vision-031021-095225

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