Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2020

Fontana Pierre, Ibberson Mark, Stevenson Brian, Wigger Leonore, Daali Youssef, Niknejad Anne, Mach François, Docquier Mylène, Xenarios Ioannis, Cuisset Thomas, Alessi Marie-Christine, Reny Jean-Luc

Abstract excerpt

BACKGROUND: On-clopidogrel platelet reactivity (PR) is associated with the risk of thrombotic or bleeding event in selected populations of high-risk patients. PR is a highly heritable phenotype and a few variants of cytochrome genes, essentially CYP2C19, are associated with PR but only explain 5% to 12% of the variability. OBJECTIVE: The aim of this study is to delineate genetic determinants of on-clopidogrel PR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clopidogrel
Share to Cytochrome P-450 CYP2C19

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exome Sequencing

Share to Genotype

Share to Platelet Aggregation

Share to Platelet Aggregation Inhibitors

Source

Identifiers

PMID: 32077582
DOI: 10.1111/jth.14776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of exome sequencing to the identification of genes involved in the response to clopidogrel in cardiovascular patients.PMID 32077582Read ↗

Clopidogrel pharmacogenetics: Beyond candidate genes and genome-wide association studies.Semantic proximity Read ↗

Genomewide Association Study of Platelet Reactivity and Cardiovascular Response in Patients Treated With Clopidogrel: A Study by the International Clopidogrel Pharmacogenomics Consortium.Semantic proximity Read ↗

Exome sequencing of extreme clopidogrel response phenotypes identifies B4GALT2 as a determinant of on-treatment platelet reactivity.Semantic proximity Read ↗

Pharmacogenomic Impact of CYP2C19 Variation on Clopidogrel Therapy in Precision Cardiovascular MedicineSemantic proximity Read ↗

Investigation of genomic and transcriptomic risk factors in clopidogrel response in African AmericansSemantic proximity Read ↗

Genetic determinants of clopidogrel responsiveness in Koreans treated with drug-eluting stents.Semantic proximity Read ↗

The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing.Semantic proximity Read ↗

Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points—Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC)Semantic proximity Read ↗

The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19.Semantic proximity Read ↗

Effects of genetic variants on platelet reactivity and one-year clinical outcomes after percutaneous coronary intervention: A prospective multicentre registry study.Semantic proximity Read ↗

Pharmacogenomics of clopidogrel: evidence and perspectives.Semantic proximity Read ↗

Next-Generation Sequencing of CYP2C19 in Stent Thrombosis: Implications for Clopidogrel Pharmacogenomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.