Article
Imbalance in DNA repair machinery is associated with BRAFV600E mutation and tumor aggressiveness in papillary thyroid carcinoma.
Molecular and cellular endocrinology - 5 Sept 2018
Lutz Bruna S, Leguisamo Natalia M, Cabral Nicole K, Gloria Helena C, Reiter Keli C, Agnes Grasiela, Zanella Virgilio, Meyer Erika L S, Saffi Jenifer
Abstract excerpt
The involvement of alterations in MLH1, an essential mismatch repair component, in BRAFV600E mutated papillary thyroid carcinoma (PTC) has been suggested to be associated with features of tumor aggressiveness. Thirty-two PTC and surrounding normal thyroid tissues were evaluated for 11 representative DNA repair genes expression. BRAFV600E mutational status assessment and clinicopathological correlations were...
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