Article
Hypermethylation of the DNA mismatch repair gene hMLH1 and its association with lymph node metastasis and T1799A BRAF mutation in patients with papillary thyroid cancer.
Cancer - 15 Jul 2008
Guan Haixia, Ji Meiju, Hou Peng, Liu Zhi, Wang Cuifang, Shan Zhongyan, Teng Weiping, Xing Mingzhao
Abstract excerpt
BACKGROUND: It remains to be investigated whether the aberrant methylation of DNA repair genes plays a pathogenic role in BRAF mutation-promoted tumorigenesis of papillary thyroid cancer (PTC). METHODS: In the current study, the promoter methylation status of 23 DNA repair genes in relation to clinicopathologic characteristics and BRAF mutation was examined in PTC tumors using methylation-specific polymerase...
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