Article
Somatic amplifications and deletions in genome of papillary thyroid carcinomas.
Endocrine - 1 Nov 2015
Passon Nadia, Bregant Elisa, Sponziello Marialuisa, Dima Maria, Rosignolo Francesca, Durante Cosimo, Celano Marilena, Russo Diego, Filetti Sebastiano, Damante Giuseppe
Abstract excerpt
Somatic gene copy number variation contributes to tumor progression. Using comparative genomic hybridization (CGH) array, the presence of genomic imbalances was evaluated in a series of 27 papillary thyroid carcinomas (PTCs). To detect only somatic imbalances, for each sample, the reference DNA was from normal thyroid tissue of the same patient. The presence of the BRAF V600E mutation was also evaluated. Both...
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