Article
Low and constant micafungin concentrations may be sufficient to lead to resistance mutations in FKS2 gene of Candida glabrata.
Medical mycology - 1 Oct 2018
Bordallo-Cardona María Ángeles, Escribano Pilar, Marcos-Zambrano Laura Judith, Díaz-García Judith, de la Pedrosa Elia Gómez, Cantón Rafael, Bouza Emilio, Guinea Jesús
Abstract excerpt
We studied the ability of five echinocandin-susceptible C. glabrata isolates to acquire in vitro resistance to anidulafungin and micafungin. All isolates became phenotypically resistant after 2-4 days of exposure to low and constant micafungin concentrations (P < .05). Mutations in the HS1 region of the FKS2 gene were found in all isolates. The acquisition of resistance was not related to the previous use of...
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