Article
In Vitro Exposure to Increasing Micafungin Concentrations Easily Promotes Echinocandin Resistance in Candida glabrata Isolates.
Antimicrobial agents and chemotherapy - 1 Feb 2017
Bordallo-Cardona María Ángeles, Escribano Pilar, de la Pedrosa Elia Gómez G, Marcos-Zambrano Laura Judith, Cantón Rafael, Bouza Emilio, Guinea Jesús
Abstract excerpt
We assessed the in vitro susceptibility of five echinocandin-susceptible Candida glabrata isolates after exposure to micafungin. The direct exposure to plates at different micafungin concentrations resulted in the inhibition of growth at 0.062 μg/ml. The progressive exposure was performed on plates using 0.031 μg/ml of micafungin and sequential propagation on plates containing the next 2-fold concentration; the...
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