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Article

Editing activity for eliminating mischarged tRNAs is essential in mammalian mitochondria.

Nucleic acids research - 25 Jan 2018

Hilander Taru, Zhou Xiao-Long, Konovalova Svetlana, Zhang Fu-Ping, Euro Liliya, Chilov Dmitri, Poutanen Matti, Chihade Joseph, Wang En-Duo, Tyynismaa Henna

Abstract excerpt

Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced by the proofreading functions of some of these enzymes for eliminating tRNAs mischarged with noncognate amino acids. Mouse models of editing-defective cytoplasmic alanyl-tRNA synthetase (AlaRS) have previously demonstrated the importance of proofreading for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29228266
DOI: 10.1093/nar/gkx1231
PMCID: PMC5778596

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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