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Article

Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy.

Proceedings of the National Academy of Sciences of the United States of America - 9 Dec 2014

Liu Ye, Satz Jakob S, Vo My-Nuong, Nangle Leslie A, Schimmel Paul, Ackerman Susan L

Abstract excerpt

Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of misfolded proteins in the heart. Reduced translational fidelity, caused by a hypomorphic mutation in the editing domain of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25422440
DOI: 10.1073/pnas.1420196111
PMCID: PMC4267364

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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