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Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review

6 Jun 2019

Abstract excerpt

Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme...

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PMID: 31176740
DOI: 10.1016/j.drudis.2019.06.002

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