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Article

Major improvement in the detection of microsatellite instability in colorectal cancer using HSP110 T17 E-ice-COLD-PCR.

Human mutation - 1 Mar 2018

How-Kit Alexandre, Daunay Antoine, Buhard Olivier, Meiller Clément, Sahbatou Mourad, Collura Ada, Duval Alex, Deleuze Jean-François

Abstract excerpt

Every colorectal cancer (CRC) patient should be tested for microsatellite instability (MSI) to screen for Lynch syndrome. Evaluation of MSI status involves screening tumor DNA for the presence of somatic deletions in DNA repeats using PCR followed by fragment analysis. While this method may lack sensitivity due to the presence of a high level of germline DNA, which frequently contaminates the core of primary...

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PMID: 29227006
DOI: 10.1002/humu.23379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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