Article
HSP110 T17 simplifies and improves the microsatellite instability testing in patients with colorectal cancer.
Journal of medical genetics - 1 Jun 2016
Buhard Olivier, Lagrange Anaïs, Guilloux Agathe, Colas Chrystelle, Chouchène Mouna, Wanherdrick Kristell, Coulet Florence, Guillerm Erell, Dorard Coralie, Marisa Laetitia, Bokhari Adem, Greene Malorie, El-Murr Nizar, Bodo Sahra, Muleris Martine, Sourouille Isabelle, Svrcek Magali, Cervera Pascale, Blanché Hélène, Lefevre Jérémie H, Parc Yann, Lepage Come, Chapusot Caroline, Bouvier Anne-Marie, Gaub Marie-Pierre, Selves Janick, Garrett Kerryn, Iacopetta Barry, Soong Richie, Hamelin Richard, Garrido Carmen, Lascols Olivier, André Thierry, Fléjou Jean-François, Collura Ada, Duval Alex
Abstract excerpt
BACKGROUND: Every colorectal cancer (CRC) patient should be tested for microsatellite instability (MSI, a marker for defective DNA mismatch repair) as a first screen for Lynch syndrome (LS). In this study, we investigated whether it may be possible to improve the detection of MSI in CRC. We examined whether the HT17 DNA repeat (critical for correct splicing of the chaperone HSP110) might constitute a superior...
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