Article
Huntingtin gene repeat size variations affect risk of lifetime depression.
Translational psychiatry - 11 Dec 2017
Gardiner Sarah L, van Belzen Martine J, Boogaard Merel W, van Roon-Mom Willeke M C, Rozing Maarten P, van Hemert Albert M, Smit Johannes H, Beekman Aartjan T F, van Grootheest Gerard, Schoevers Robert A, Oude Voshaar Richard C, Roos Raymund A C, Comijs Hannie C, Penninx Brenda W J H, van der Mast Roos C, Aziz N Ahmad
Abstract excerpt
Huntington disease (HD) is a severe neuropsychiatric disorder caused by a cytosine-adenine-guanine (CAG) repeat expansion in the HTT gene. Although HD is frequently complicated by depression, it is still unknown to what extent common HTT CAG repeat size variations in the normal range could affect depression risk in the general population. Using binary logistic regression, we assessed the association between HTT...
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