Article
Prevalence of incompletely penetrant Huntington's disease alleles among individuals with major depressive disorder.
The American journal of psychiatry - 1 May 2010
Perlis Roy H, Smoller Jordan W, Mysore Jayalakshmi, Sun Mei, Gillis Tammy, Purcell Shaun, Rietschel Marcella, Nöthen Markus M, Witt Stephanie, Maier Wolfgang, Iosifescu Dan V, Sullivan Patrick, Rush A John, Fava Maurizio, Breiter Hans, Macdonald Marcy, Gusella James
Abstract excerpt
OBJECTIVE: Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations. However, the prevalence of HTT CAG repeat expansions among individuals diagnosed with major depressive disorder has not been established. METHOD: This was a case-control genetic association study of HTT CAG allele...
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