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Article

Truncated mutants of human thioredoxin reductase 1 do not exhibit glutathione reductase activity.

FEBS letters - 26 Jun 2006

Urig Sabine, Lieske Johanna, Fritz-Wolf Karin, Irmler Angelika, Becker Katja

Abstract excerpt

The substrate spectrum of human thioredoxin reductase (hTrxR) is attributed to its C-terminal extension of 16 amino acids carrying a selenocysteine residue. The concept of an evolutionary link between thioredoxin reductase and glutathione reductase (GR) is presently discussed and supported by the fact that almost all residues at catalytic and substrate recognition sites are identical. Here, we addressed the...

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PMID: 16750198
DOI: 10.1016/j.febslet.2006.05.038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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