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Article

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.

Neuron - 6 Dec 2017

Huynh Tien-Phat V, Liao Fan, Francis Caroline M, Robinson Grace O, Serrano Javier Remolina, Jiang Hong, Roh Joseph, Finn Mary Beth, Sullivan Patrick M, Esparza Thomas J, Stewart Floy R, Mahan Thomas E, Ulrich Jason D, Cole Tracy, Holtzman David M

Abstract excerpt

The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease. Previous studies suggest that reduction of apoE levels through genetic manipulation can reduce Aβ pathology. However, it is not clear how reduction of apoE levels after birth would affect amyloid deposition. We utilize an antisense oligonucleotide (ASO) to reduce apoE expression in the brains of APP/PS1-21 mice...

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Share to Amyloid beta-Peptides
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloidosis

Share to Apolipoprotein E3

Share to Apolipoprotein E4

Share to Apolipoproteins E

Share to Oligonucleotides, Antisense

Share to Plaque, Amyloid

Source

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Identifiers

PMID: 29216448
DOI: 10.1016/j.neuron.2017.11.014
PMCID: PMC5728673

Genes

APOE
APP

Provenance

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