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Article

Alphaherpesvirus axon-to-cell spread involves limited virion transmission

1 Oct 2012

Abstract excerpt

The spread of viral infection within a host can be restricted by bottlenecks that limit the size and diversity of the viral population. An essential process for alphaherpesvirus infection is spread from axons of peripheral nervous system neurons to cells in peripheral epithelia (anterograde-directed spread, ADS). ADS is necessary for the formation of vesicular lesions characteristic of reactivated herpesvirus...

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PMID: 23027939
DOI: 10.1073/pnas.1212926109

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