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Article

Anterograde transneuronal tracing and genetic control with engineered yellow fever vaccine YFV-17D.

Nature methods - 1 Dec 2021

Li Elizabeth, Guo Jun, Oh So Jung, Luo Yi, Oliveros Heankel Cantu, Du Wenqin, Arano Rachel, Kim Yerim, Chen Yuh-Tarng, Eitson Jennifer, Lin Da-Ting, Li Ying, Roberts Todd, Schoggins John W, Xu Wei

Abstract excerpt

Transneuronal viruses are powerful tools for tracing neuronal circuits or delivering genes to specific neurons in the brain. While there are multiple retrograde viruses, few anterograde viruses are available. Further, available anterograde viruses often have limitations such as retrograde transport, high neuronal toxicity or weak signals. We developed an anterograde viral system based on a live attenuated vaccine...

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Identifiers

PMID: 34824475
DOI: 10.1038/s41592-021-01319-9
PMCID: PMC8665090

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