Article
Subcellular Localization and Functional Characterization of GII.4 Norovirus-Encoded NTPase.
Journal of virology - 1 Mar 2018
Yen Ju-Bei, Wei Ling-Huei, Chen Lee-Wen, Chen Li-Yu, Hung Chien-Hui, Wang Shie-Shan, Chang Pey-Jium
Abstract excerpt
The genotype II.4 (GII.4) variants of human noroviruses (HuNVs) are recognized as the major agent of global gastroenteritis outbreaks. Due to the lack of an efficient cell culture system for HuNV propagation, the exact roles of HuNV-encoded nonstructural proteins (including Nterm, NTPase, P22, VPg, Pro, and RdRp) in viral replication or pathogenesis have not yet been fully understood. Here, we report the...
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