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Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production

15 Aug 2024

Abstract excerpt

Flaviviridae is a family of positive-stranded RNA viruses, including human pathogens, such as Japanese encephalitis virus (JEV), dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV). Nuclear localization of the viral core protein is conserved among Flaviviridae, and this feature may be targeted for developing broad-ranging anti-flavivirus drugs. However, the mechanism of core protein translocation to...

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PMID: 39146232
DOI: 10.1371/journal.ppat.1012409

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