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Article

Common complement factor H polymorphisms are linked with periodontitis in elderly patients.

Journal of periodontology - 1 Nov 2022

Salminen Aino, Pietiäinen Milla, Paju Susanna, Sorsa Timo, Mäntylä Päivi, Buhlin Kåre, Sinisalo Juha, Pussinen Pirkko J

Abstract excerpt

BACKGROUND: In our recent genome-wide association study, we found that genetic polymorphisms in the complement factor H (CFH) gene and S100A gene region are strongly associated with serum matrix metalloproteinase 8 (MMP-8) concentration and the release of MMP-8 from neutrophils. As MMP-8 is centrally involved in the pathogenesis of periodontitis, we aimed to evaluate the presence of genetic polymorphisms of...

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Identifiers

PMID: 35315933
DOI: 10.1002/JPER.22-0005
PMCID: PMC10084333

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