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Article

Speech- and language-linked FOXP2 mutation targets protein motors in striatal neurons.

Brain : a journal of neurology - 1 Aug 2023

Kuo Hsiao-Ying, Chen Shih-Yun, Huang Rui-Chi, Takahashi Hiroshi, Lee Yen-Hui, Pang Hao-Yu, Wu Cheng-Hsi, Graybiel Ann M, Liu Fu-Chin

Abstract excerpt

Human speech and language are among the most complex motor and cognitive abilities. The discovery of a mutation in the transcription factor FOXP2 in KE family members with speech disturbances has been a landmark example of the genetic control of vocal communication in humans. Cellular mechanisms underlying this control have remained unclear. By leveraging FOXP2 mutation/deletion mouse models, we found that the KE...

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Source

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Identifiers

PMID: 37137515
DOI: 10.1093/brain/awad090
PMCID: PMC10393416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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