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Article

Pre-existing mutations in reverse transcriptase of hepatitis B virus in treatment-naive Chinese patients with chronic hepatitis B.

PloS one - 1 Jan 2015

Xu Jie, Wu Biao, Wang Jing-Hui, Huang Ling, Wang Deng-Yu, Zhao Ling, Zhao Guo-Ping, Wang Ying

Abstract excerpt

High rate of viral replication and lacking of proofreading activity in hepatitis B virus (HBV) polymerase lead to the generation of mutations in HBV virus. Mutations in the reverse transcriptase (RT) region of HBV polymerase are demonstrated to be strongly associated with drug resistance during antiviral treatment. However, the presence of mutations as well as its clinical significance in treatment-naïve...

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Identifiers

PMID: 25821965
DOI: 10.1371/journal.pone.0117429
PMCID: PMC4379075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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