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Article

Neonatal neutrophils stimulated by group B Streptococcus induce a proinflammatory T-helper cell bias.

Pediatric research - 1 Mar 2018

Lin Jianguo, Haridas Seema, Barenkamp Stephen J, Lorenset Larissa Chioquetta, Lee Ashley Sang Eun, Schroeder Benjamin T, Peng Guangyong, Koenig Joyce M

Abstract excerpt

BackgroundGroup B Streptococcus (GBS) infection causes inflammatory comorbidities in newborns. While the mechanisms remain unclear, evidence suggests that impaired innate-adaptive immune interactions may be contributory. We hypothesized that GBS-stimulated neonatal neutrophils provide a milieu that may drive proinflammatory T-helper (Th) cell programming.MethodsNeutrophils were stimulated with Type III GBS...

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Identifiers

PMID: 29211057
DOI: 10.1038/pr.2017.272
PMCID: PMC5902646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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