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Article

Molecular mechanisms underlying anti-inflammatory phenotype of neonatal splenic macrophages.

Journal of leukocyte biology - 1 Aug 2007

Chelvarajan Lakshman, Popa Diana, Liu Yushu, Getchell Thomas V, Stromberg Arnold J, Bondada Subbarao

Abstract excerpt

Neonatal humans and rodents are susceptible to infection with encapsulated bacteria as a result of an inability to make antibodies to capsular polysaccharides. This is partly a result of decreased production of proinflammatory cytokines by splenic macrophages (MPhi) from neonates. In this study, we show that when stimulated with a variety of agonists to TLR2, -4, and -9, neonatal MPhi make less proinflammatory...

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Identifiers

PMID: 17495050
DOI: 10.1189/jlb.0107071

Genes

TLR2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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