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Article

Monitoring of MYD88 L265P mutation by droplet digital polymerase chain reaction for prediction of early relapse in a patient with Bing-Neel syndrome.

International journal of hematology - 1 Apr 2021

Shikata Hisaharu, Kihara Hisafumi, Kaneko Masahiko, Matsukage Shoichi, Hattori Keiichiro

Abstract excerpt

Bing-Neel syndrome (BNS) is a rare neurologic complication of lymphoplasmacytic lymphoma (LPL) characterized by direct infiltration of lymphoplasmacytic cells (LPCs). Although no standard treatment has yet been established, patients with BNS harboring the MYD88 L265P mutation have been reported to respond favorably to ibrutinib, which can cross the blood-brain barrier and trigger apoptosis of MYD88 L265P-positive...

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PMID: 33222046
DOI: 10.1007/s12185-020-03038-x

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