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Article

Dysregulated inflammasome activity in intestinal inflammation - Insights from patients with very early onset IBD.

Frontiers in immunology - 1 Jan 2022

Illig David, Kotlarz Daniel

Abstract excerpt

Inflammatory bowel disease (IBD) is a multifactorial disorder triggered by imbalances of the microbiome and immune dysregulations in genetically susceptible individuals. Several mouse and human studies have demonstrated that multimeric inflammasomes are critical regulators of host defense and gut homeostasis by modulating immune responses to pathogen- or damage-associated molecular patterns. In the context of...

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Identifiers

PMID: 36524121
DOI: 10.3389/fimmu.2022.1027289
PMCID: PMC9744759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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