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Article

Reproducibility over time of the urinary diclofenac/4'-OH diclofenac ratio among different CYP2C9 genotypes.

European journal of drug metabolism and pharmacokinetics - 1 Jan 2000

Dorado Pedro, Berecz Roland, Cáceres Macarena C, Conzález Idilio, Llerena Adrián

Abstract excerpt

Diclofenac has been used for the evaluation of CYP2C9 activity in vitro as well as in vivo with varying results. The present study was aimed at evaluating the reproducibility of the urinary diclofenac/4'-OH diclofenac ratio among different CYP2C9 genotypes in healthy volunteers. The study of CYP2C9 genotypes in the family of a CYP2C9*3/*3 subject is also reported. The urinary diclofenac/4'-OH diclofenac ratio was...

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PMID: 14527094
DOI: 10.1007/BF03190487

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