Article
COMT and age at onset in mood disorders: a replication and extension study.
Neuroscience letters - 12 Jul 2011
Massat Isabelle, Kocabas Neslihan Aygun, Crisafulli Concetta, Chiesa Alberto, Calati Raffaella, Linotte Sylvie, Kasper Siegfried, Fink Martin, Antonijevic Irina, Forray Carlos, Snyder Lenore, Bollen Joseph, Zohar Joseph, De Ronchi Diana, Souery Daniel, Serretti Alessandro, Mendlewicz Julien
Abstract excerpt
Our study aims at replicating our previous finding of an association between COMT rs4680 G/A polymorphism and early onset major depression (MD). We included 462 MD, 147 bipolar disorders (BD) subjects and 295 healthy controls. We could partially replicate previous findings. In particular, rs4680 GG+AG genotypes were more represented in the subgroup of early onset MD patients (p=0.04). Additionally, we observed an...
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