Article
Genome-wide association meta-analysis of age at first cannabis use.
Addiction (Abingdon, England) - 1 Nov 2018
Minică Camelia C, Verweij Karin J H, van der Most Peter J, Mbarek Hamdi, Bernard Manon, van Eijk Kristel R, Lind Penelope A, Liu Meng Zhen, Maciejewski Dominique F, Palviainen Teemu, Sánchez-Mora Cristina, Sherva Richard, Taylor Michelle, Walters Raymond K, Abdellaoui Abdel, Bigdeli Timothy B, Branje Susan J T, Brown Sandra A, Casas Miguel, Corley Robin P, Davey-Smith George, Davies Gareth E, Ehli Erik A, Farrer Lindsay, Fedko Iryna O, Garcia-Martínez Iris, Gordon Scott D, Hartman Catharina A, Heath Andrew C, Hickie Ian B, Hickman Matthew, Hopfer Christian J, Hottenga Jouke Jan, Kahn René S, Kaprio Jaakko, Korhonen Tellervo, Kranzler Henry R, Krauter Ken, van Lier Pol A C, Madden Pamela A F, Medland Sarah E, Neale Michael C, Meeus Wim H J, Montgomery Grant W, Nolte Ilja M, Oldehinkel Albertine J, Pausova Zdenka, Ramos-Quiroga Josep A, Richarte Vanesa, Rose Richard J, Shin Jean, Stallings Michael C, Wall Tamara L, Ware Jennifer J, Wright Margaret J, Zhao Hongyu, Koot Hans M, Paus Tomas, Hewitt John K, Ribasés Marta, Loukola Anu, Boks Marco P, Snieder Harold, Munafò Marcus R, Gelernter Joel, Boomsma Dorret I, Martin Nicholas G, Gillespie Nathan A, Vink Jacqueline M, Derks Eske M
Abstract excerpt
BACKGROUND AND AIMS: Cannabis is one of the most commonly used substances among adolescents and young adults. Earlier age at cannabis initiation is linked to adverse life outcomes, including multi-substance use and dependence. This study estimated the heritability of age at first cannabis use and identified associations with genetic variants. METHODS: A twin-based heritability analysis using 8055 twins from three...
Read the complete abstract on PubMed