Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.

Cellular immunology - 1 Feb 2018

Melsted Wenna Nascimento, Matzen Sara Hyldig, Andersen Mads Hald, Hviid Thomas Vauvert F

Abstract excerpt

An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, increases the expression of HLA-G+CD4+ and CD8+ T cells, and decreases the expression of ILT2+ on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Choriocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-G Antigens

Share to Interleukin-17

Share to Leukocytes, Mononuclear

Share to T-Lymphocytes, Regulatory

Share to Trophoblasts

Share to Uterine Neoplasms

Source

Identifiers

PMID: 29198970
DOI: 10.1016/j.cellimm.2017.11.008

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The choriocarcinoma cell line JEG-3 upregulates regulatory T cell phenotypes and modulates pro-inflammatory cytokines through HLA-G.PMID 29198970Read ↗

Extravillous trophoblast model shows generation of bioequivalent N-glycans can maintain immunological protection against natural killer cell cytotoxicitySemantic proximity Read ↗

Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytesSemantic proximity Read ↗

Application of a JEG-3 organoid model to study HLA-G function in the trophoblastSemantic proximity Read ↗

Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitroSemantic proximity Read ↗

Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory propertiesSemantic proximity Read ↗

Human leukocyte antigens: the unique expression in trophoblasts and their crosstalk with local immune cellsSemantic proximity Read ↗

Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal InterfaceSemantic proximity Read ↗

Primary Trophoblast Cultures: Characterization of HLA Profiles and Immune Cell InteractionsSemantic proximity Read ↗

HLA-G Orchestrates the Early Interaction of Human Trophoblasts with the Maternal NicheSemantic proximity Read ↗

Human Chorionic Gonadotropin modulates CXCL10 Expression through Histone Methylation in human deciduaSemantic proximity Read ↗

Human Chorionic Gonadotropin as a Pivotal Endocrine Immune Regulator Initiating and Preserving Fetal ToleranceSemantic proximity Read ↗

Human Chorionic Gonadotropin-Mediated Immune Responses That Facilitate Embryo Implantation and PlacentationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.