Article
A Selection Operator for Summary Association Statistics Reveals Allelic Heterogeneity of Complex Traits.
American journal of human genetics - 7 Dec 2017
Ning Zheng, Lee Youngjo, Joshi Peter K, Wilson James F, Pawitan Yudi, Shen Xia
Abstract excerpt
In recent years, as a secondary analysis in genome-wide association studies (GWASs), conditional and joint multiple-SNP analysis (GCTA-COJO) has been successful in allowing the discovery of additional association signals within detected loci. This suggests that many loci mapped in GWASs harbor more than a single causal variant. In order to interpret the underlying mechanism regulating a complex trait of interest...
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