Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment.

doi:10.1016/j.ajhg.2017.10.001

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Article

Multiethnic GWAS Reveals Polygenic Architecture of Earlobe Attachment.

American journal of human genetics - 7 Dec 2017

Shaffer John R, Li Jinxi, Lee Myoung Keun, Roosenboom Jasmien, Orlova Ekaterina, Adhikari Kaustabh, Gallo Carla, Poletti Giovanni, Schuler-Faccini Lavinia, Bortolini Maria-Cátira, Canizales-Quinteros Samuel, Rothhammer Francisco, Bedoya Gabriel, González-José Rolando, Pfeffer Paige E, Wollenschlaeger Christopher A, Hecht Jacqueline T, Wehby George L, Moreno Lina M, Ding Anan, Jin Li, Yang Yajun, Carlson Jenna C, Leslie Elizabeth J, Feingold Eleanor, Marazita Mary L, Hinds David A, Cox Timothy C, Wang Sijia, Ruiz-Linares Andrés, Weinberg Seth M

Abstract excerpt

The genetic basis of earlobe attachment has been a matter of debate since the early 20th century, such that geneticists argue both for and against polygenic inheritance. Recent genetic studies have identified a few loci associated with the trait, but large-scale analyses are still lacking. Here, we performed a genome-wide association study of lobe attachment in a multiethnic sample of 74,660 individuals from four...

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Identifiers

PMID: 29198719
DOI: 10.1016/j.ajhg.2017.10.001
PMCID: PMC5812923

Genes

ADGRG6
EDAR
MRPS22
PAX9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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