Article
Deficits in verbal fluency in presymptomatic C9orf72 mutation gene carriers-a developmental disorder.
Journal of neurology, neurosurgery, and psychiatry - 1 Nov 2020
Lulé Dorothée E, Müller Hans-Peter, Finsel Julia, Weydt Patrick, Knehr Antje, Winroth Ivar, Andersen Peter, Weishaupt Jochen, Uttner Ingo, Kassubek Jan, Ludolph Albert C
Abstract excerpt
BACKGROUND: A mutation in C9orf72 constitute a cross-link between amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD). At clinical manifestation, both patient groups may present with either cognitive impairment of predominantly behaviour or language (in FTD) or motor dysfunctions (in ALS). METHODS: In total, 36 non-symptomatic mutation carriers from ALS or FTD families were examined, including...
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