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Connectivity Map-based discovery of parbendazole reveals targetable human osteogenic pathway

29 Sept 2015

Abstract excerpt

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. In this study, we have identified pathways that stimulate differentiation of bone forming osteoblasts from human mesenchymal stromal cells (hMSCs). Gene expression profiling was performed in hMSCs differentiated toward osteoblasts (at 6 h). Significantly regulated genes were...

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PMID: 26420877
DOI: 10.1073/pnas.1501597112

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