Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials.

doi:10.1016/j.ejca.2021.03.034

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Article

Risk factors and outcomes in children with high-risk B-cell precursor and T-cell relapsed acute lymphoblastic leukaemia: combined analysis of ALLR3 and ALL-REZ BFM 2002 clinical trials.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2021

Eckert Cornelia, Parker Catriona, Moorman Anthony V, Irving Julie Ae, Kirschner-Schwabe Renate, Groeneveld-Krentz Stefanie, Révész Tamas, Hoogerbrugge Peter, Hancock Jeremy, Sutton Rosemary, Henze Guenter, Chen-Santel Christiane, Attarbaschi Andishe, Bourquin Jean-Pierre, Sramkova Lucie, Zimmermann Martin, Krishnan Shekhar, von Stackelberg Arend, Saha Vaskar

Abstract excerpt

AIM: Outcomes of children with high-risk (HR) relapsed acute lymphoblastic leukaemia (ALL) (N = 393), recruited to ALLR3 and ALL-REZ BFM 2002 trials, were analysed. Minimal residual disease (MRD) was assessed after induction and at predetermined time points until haematopoietic stem cell transplantation (SCT). METHODS: Genetic analyses included karyotype, copy-number alterations and mutation analyses. Ten-year...

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PMID: 34010787
DOI: 10.1016/j.ejca.2021.03.034

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