Article
Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial).
The American journal of cardiology - 15 Jan 2018
Leary Peter J, Kronmal Richard A, Bluemke David A, Buttrick Peter M, Jones Kenneth L, Kao David P, Kawut Steven M, Krieger Eric V, Lima Joao A, Minobe Wayne, Ralph David D, Tedford Ryan J, Weiss Noel S, Bristow Michael R
Abstract excerpt
Myocardial H2 receptor activation contributes to heart failure (HF) in preclinical models, and H2 receptor antagonists are associated with decreased HF incidence. This study evaluated whether H2 histamine receptor (HRH2) single nucleotide polymorphisms (SNPs) are associated with HF incidence and whether myocardial transcript abundance is associated with HF recovery. The association of SNPs in HRH2 with incident...
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