Article
Heart Rate Reduction Is Associated With Reverse Left Ventricular Remodeling and Mechanism-Specific Molecular Phenotypes in Dilated Cardiomyopathy.
Circulation. Heart failure - 1 Apr 2025
Altman Natasha L, Gill Edward A, Kahwash Rami, Meyer Leslie K, Wagner Jessica A, Karimpour-Fard Anis, Berning Amber A, Minobe Wayne A, Carroll Ian A, Jonas Eric R, Slavov Dobromir, Emani Sitaramesh, Abraham William T, Gollah Alexa R, Ellis Samuel L, Taylor Matthew R G, Graw Sharon L, Mestroni Luisa, McKinsey Timothy A, Buttrick Peter M, Kao David P, Bristow Michael R
Abstract excerpt
BACKGROUND: Heart rate (HR) affects heart failure outcomes, via uncertain mechanisms that may include left ventricular remodeling. However, in human ventricular myocardium, HR change has not been associated with a particular remodeling molecular phenotype. METHODS: Patients with nonischemic dilated cardiomyopathy (N=22) in sinus rhythm and refractory to β-blockade for both HR lowering and reverse remodeling were...
Read the complete abstract on PubMedTopics
- Humans
- Cardiomyopathy, Dilated
- Ventricular Remodeling
- Male