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Article

HLA and non-HLA genes and familial predisposition to autoimmune diseases in families with a child affected by type 1 diabetes.

PloS one - 1 Jan 2017

Parkkola Anna, Laine Antti-Pekka, Karhunen Markku, Härkönen Taina, Ryhänen Samppa J, Ilonen Jorma, Knip Mikael

Abstract excerpt

Genetic predisposition could be assumed to be causing clustering of autoimmunity in individuals and families. We tested whether HLA and non-HLA loci associate with such clustering of autoimmunity. We included 1,745 children with type 1 diabetes from the Finnish Pediatric Diabetes Register. Data on personal or family history of autoimmune diseases were collected with a structured questionnaire and, for a subset,...

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Share to Autoimmune Diseases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Diabetes Mellitus, Type 1

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 29182645
DOI: 10.1371/journal.pone.0188402
PMCID: PMC5705143

Genes

CCR3
CCR5
RGS1
FUT2
NRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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