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Article

Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.

Journal of human genetics - 1 Feb 2018

Uno Narumi, Abe Satoshi, Oshimura Mitsuo, Kazuki Yasuhiro

Abstract excerpt

Chromosome transfer technology, including chromosome modification, enables the introduction of Mb-sized or multiple genes to desired cells or animals. This technology has allowed innovative developments to be made for models of human disease and humanized animals, including Down syndrome model mice and humanized transchromosomic (Tc) immunoglobulin mice. Genome editing techniques are developing rapidly, and...

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Identifiers

PMID: 29180645
DOI: 10.1038/s10038-017-0378-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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