Article
An approach to identify new genes in autoimmune diseases: lessons from rheumatoid arthritis.
Reviews in immunogenetics - 1 Jan 2000
Shiozawa S, Komai K, Konishi Y, Hikasa M, Mukae N, Shiozawa K, Kitagawa M, Yoshikawa N, Kawasaki H
Abstract excerpt
We have searched the human genome for genes that predispose to rheumatoid arthritis using fluorescence-based microsatellite marker analysis and affected sib-pair linkage studies. A panel of 41 Japanese families, each with at least two affected siblings, was typed for genome-wide 358 polymorphic microsatellite marker loci. Three principal chromosome regions of linkage, D1S253/214, D8S556 and DX1232, have been...
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