Article
Genes and gene networks implicated in aggression related behaviour.
Neurogenetics - 1 Oct 2014
Malki Karim, Pain Oliver, Du Rietz Ebba, Tosto Maria Grazia, Paya-Cano Jose, Sandnabba Kenneth N, de Boer Sietse, Schalkwyk Leonard C, Sluyter Frans
Abstract excerpt
Aggressive behaviour is a major cause of mortality and morbidity. Despite of moderate heritability estimates, progress in identifying the genetic factors underlying aggressive behaviour has been limited. There are currently three genetic mouse models of high and low aggression created using selective breeding. This is the first study to offer a global transcriptomic characterization of the prefrontal cortex...
Topics
- Aggression
- Animals
- Disease Models, Animal
- Female
- Gene Expression Profiling
- Gene Regulatory Networks
- Genetic Variation
- MAP Kinase Signaling System
- Male
- Mice
- Mice, Inbred Strains
- Prefrontal Cortex