Article
An integrated analysis of genes and functional pathways for aggression in human and rodent models.
Molecular psychiatry - 1 Nov 2019
Zhang-James Yanli, Fernàndez-Castillo Noèlia, Hess Jonathan L, Malki Karim, Glatt Stephen J, Cormand Bru, Faraone Stephen V
Abstract excerpt
Human genome-wide association studies (GWAS), transcriptome analyses of animal models, and candidate gene studies have advanced our understanding of the genetic architecture of aggressive behaviors. However, each of these methods presents unique limitations. To generate a more confident and comprehensive view of the complex genetics underlying aggression, we undertook an integrated, cross-species approach. We...
Topics
- Aggression
- Animals
- Databases, Genetic
- Emotions
- Gene Expression Profiling
- Gene Regulatory Networks
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Mice